Cardioprotective Effect of Cornus Mas Fruit Extract against Carbon Tetrachloride Induced-Cardiotoxicity in Albino Rats
نویسندگان
چکیده
In the present study, cardioprotective effect of Cornus mas fruits extract (CMFE) was evaluated in a rat model having acute cardiotoxicity, induced by single dose of carbon tetrachloride (CCl4) (1ml/kg i.p.). Pre and post treatment of C. mas fruit extract (300 and 700mg/kg) in CCl4-treated rats significantly decreased the increased levels of serum lactate dehydrogenase, serum creatine kinase and myocardial lipid peroxides and significantly increased the myocardial endogenous antioxidants (glutathione peroxidase, superoxide dismutase and catalase) levels. The results of biochemical observations in the serum and heart tissues were supplemented by histological examination of rats’ heart sections to confirm the myocardial injury. The present results provide evidence for the first time, that Cornus mas fruit extract (CMFE) treatment ameliorated myocardial injury and enhanced the antioxidant defense against CCl4-induced cardiotoxicity in rats and exhibited cardioprotective properties.
منابع مشابه
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متن کاملHepatoprotective Effect of Cornus mas Fruits Extract Against Carbon Tetrachloride-Induced Hepatic Damage in Male Albino Rats
1Liver and Gastrointestinal Diseases Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran 2Department of Biology, Faculty of Sciences, University of Tabriz, Tabriz, IR Iran 3Drug Applied Research Center, School of Medicine, Tabriz University of Medical Sciences, Tabriz, IR Iran 4Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, ...
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